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KMID : 1134820130420101585
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Journal of the Korean Society of Food Science and Nutrition
2013 Volume.42 No. 10 p.1585 ~ p.1591
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Effects of Exercise Training on the Relationship with Brain-derived Neurotrophic Factor Expression and Leptin mRNA Expression in Hypothalamus, Serum Leptin, and Anti-obesity in High-fat Diet-induced Obese Rats
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Woo Sang-Heon
Kang Sung-Hwun
Woo Jin-Hee
Shin Ki-Ok
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Abstract
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The purpose of this study is to examine how to relate with hypothalamus protein BDNF and mRNA leptin expression, and test the effect of exercise training upon anti-obesity in high-fat induced obese rats. Weight and plasma TC of the high-fat diet group (HF) significantly reduced in comparison to those in the high-fat diet and training group (HF-T), high-fat diet and normal diet group (HF-ND), and high-fat diet, training, and normal diet group (HF-ND+T) (P<0.05). Plasm TG of the HF group significantly decreased in comparison to the HF-ND+T group (P< 0.05). The plasma leptin level significantly reduced in the HF-T group in comparison to the HF group, in the HF-ND group compared to the HF-T group, and the HF-ND+T group in comparison to the HF-ND group (P<0.05, respectively). All groups were significantly increased in hypothalamus BDNF protein expression in comparison to the HF group. In hypothalamus leptin mRNA expression, the HF-T and HF-ND groups reduced, but the HF-NF+T group increased in comparison to the HF group. This result suggests that it shows the effect of exercise training upon anti-obesity in high-fat diet induced obese rats and the combined exercise and/or normal diet may affect the optimal obesity improvement and prevention in appetite and weight control.
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KEYWORD
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exercise, high-fat diet, BDNF, leptin, obesity
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